Serum & Plasma – Proteomics Consortium

Use of Hybrid Data-Dependent and -Independent Acquisition Spectral Libraries Empowers Dual-Proteome Profiling

By Hugh Dixon
April 16, 2021
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In the context of bacterial infections, it’s crucial that physiological responses could be studied in an built-in method, which means a simultaneous evaluation of each the host and the pathogen … Continue Reading →

$The identification of specific protein kinases as oncogenic drivers in a variety of cancer sorts, coupled with the clinical success of particular kinase-directed targeted therapies, has cemented the human kinome as an attractive source of 'actionable' targets for cancer remedy. However, 'mining' of the human kinome for precision oncology applications has yet to yield its full potential. This reflects a variety of points, including oncogenic kinase dysregulation at levels not detectable by genomic sequencing and the uncharacterized nature of a considerable fraction of the kinome. In addition, selective therapeutic targeting of specific kinases requires efficient mapping of total kinome space impacted by candidate small molecule medication. Fortunately, recent developments in proteomics strategies, particularly in mass spectrometry-based phosphoproteomics and kinomics, provide the necessary technology platforms to address these impediments. Moreover, initiatives such as the Clinical Proteomic Tumour Analysis Consortium have enabled the era, deposition and integration of genomic, transcriptomic and (phospho)proteomic data for many cancer sorts, providing unprecedented insights into oncogenic kinases and cancer cell signalling typically. These multi-omic data are identifying novel therapeutic targets, highlighting opportunities for drug re-purposing, and helping assign optimal therapies to specific tumour subtypes, heralding a new era of 'enhanced' precision oncology. This article is protected by copyright. All rights reserved.$

Human pores and skin is composed of the cell-rich dermis, the extracellular matrix (ECM) wealthy dermis, and the hypodermis.

By Hugh Dixon
April 11, 2021
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Within the dermis, a dense community of ECM proteins offers structural assist to the pores and skin and regulates a large variety of signaling pathways which govern cell proliferation and … Continue Reading →

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

By Hugh Dixon
March 11, 2021
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Proteomic signatures associated with medical measures of extra aggressive cancers may yield molecular clues as to illness drivers. Here, using the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets, we outlined differentially expressed proteins and mRNAs … Continue Reading →

An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community

By Hugh Dixon
March 11, 2021
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Precise multiplexed quantification of proteins in organic samples will be achieved by focused proteomics utilizing a number of or parallel response monitoring (MRM/PRM). Combined with inside requirements, the methodology achieves excellent repeatability … Continue Reading →

Protease Free Heat Shock Bovine Serum Equitech Bio

By Hugh Dixon
January 12, 2020
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Catalog Number: 135-BAH65-50G Category: Serum Supplier: Equitech Bio Species: Bovine To order Protease Free Heat Shock Bovine Serum from Equitech Bio Contact info@proteomeconsortium.org Oxiselect Uv Induced DNA Damage Elisa Antigen … Continue Reading →

Pooled Human Plasma Apheresis Derived Innovative Research

By Hugh Dixon
January 12, 2020
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Catalog Number: 109-IPLA-L-IH-100 Category: Plasma Supplier: Innovative Research Species: Human To order Pooled Human Plasma Apheresis Derived from Innovative Research Contact info@proteomeconsortium.org Recombinant E.Coli Porcine Circovirus Fitc Conjugated Ulex Europaeus … Continue Reading →

Rainbow Trout Serum Sterile Filtered Caisson Labs

By Hugh Dixon
January 12, 2020
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Catalog Number: 511-TSL01-10ML Category: Serum Supplier: Caisson Laboratories To order Rainbow Trout Serum Sterile Filtered from Caisson Laboratories Contact info@proteomeconsortium.org Monkey Prostate Total RNA Cynomolgus Recombinant Human Granulocyte Colony Fatty … Continue Reading →

Apolipoprotein A1 Human Plasma Hdl Molecular Innovations

By Hugh Dixon
January 12, 2020
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Catalog Number: 52-MI-HAPO-A1-B Category: Plasma Supplier: Molecular Innovations Inc Species: Human To order Apolipoprotein A1 Human Plasma Hdl from Molecular Innovations Inc Contact info@proteomeconsortium.org Total Oxidant Status Tos Assay Kit … Continue Reading →

Rat Serum Paraoxanase Lactonase 3 Mybiosource

By Hugh Dixon
January 12, 2020
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Catalog Number: 544-MBS2881619-96 Category: Serum Supplier: Mybiosource Species: Rat To order Rat Serum Paraoxanase Lactonase 3 from Mybiosource Contact info@proteomeconsortium.org Human Vip Rapid Cempetitive Elisa Quantichrom Bcg Albumin Assay Kit … Continue Reading →

Fetal Bovine Serum South America Labtech

By Hugh Dixon
January 12, 2020
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Catalog Number: 47-FB-1001H/500 Category: Serum Supplier: Labtech Species: Bovine To order Fetal Bovine Serum South America from Labtech Contact info@proteomeconsortium.org Rat Serum Paraoxanase Lactonase 3 Human Vip Rapid Cempetitive Elisa … Continue Reading →

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