Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

Proteomic signatures associated with medical measures of extra aggressive cancers may yield molecular clues as to illness drivers. Here, using the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets, we outlined differentially expressed proteins and mRNAs associated with larger grade or larger stage, for every of seven most cancers varieties (breast, colon, lung adenocarcinoma, clear cell renal, ovarian, uterine, and pediatric glioma), representing 794 sufferers. Widespread differential patterns of whole proteins and phosphoproteins concerned some frequent patterns shared between totally different most cancers varieties.

More proteins have been associated with larger grade than larger stage. Most proteomic signatures predicted affected person survival in unbiased transcriptomic datasets. The proteomic grade signatures, particularly, concerned DNA copy quantity alterations. Pathways of curiosity have been enriched throughout the grade-associated proteins throughout a number of most cancers varieties, together with pathways of altered metabolism, Warburg-like results, and translation elements. Proteomic grade correlations recognized protein kinases having useful affect in vitro in uterine endometrial most cancers cells, together with MAP3K2, MASTL, and TTK.

The protein-level grade and stage associations for all proteins profiled-along with corresponding data on phosphorylation, pathways, mRNA expression, and copy alterations-represent a useful resource for figuring out new potential targets. Proteomic analyses are sometimes concordant with corresponding transcriptomic analyses, however with notable exceptions. Performing large-scale plasma proteome profiling is difficult as a result of limitations imposed by prolonged preparation and instrument time. We current a totally automated multiplexed proteome profiling platform (AutoMP3) utilizing the Hamilton Vantage liquid dealing with robotic succesful of making ready lots of to 1000’s of samples.

To maximize protein depth in single-shot runs, we mixed 16-plex Tandem Mass Tags (TMTpro) with high-field uneven waveform ion mobility spectrometry (FAIMS Pro) and real-time search (RTS). We quantified over 40 proteins/min/pattern, doubling the beforehand printed charges. We utilized AutoMP3 to analyze the bare mole-rat plasma proteome each as a operate of the circadian cycle and in response to ultraviolet (UV) remedy. In preserving with the dearth of synchronized circadian rhythms in bare mole-rats, we discover few circadian patterns in plasma proteins over the course of 48 h. Furthermore, we quantify many disparate modifications between mice and bare mole-rats at each 48 h and one week after UV publicity.

Simplified and Unified Access to Cancer Proteogenomic Data

Comprehensive most cancers information units lately generated by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) supply nice potential for advancing our understanding of how one can fight most cancers. These information units embrace DNA, RNA, protein, and medical characterization for tumor and regular samples from giant cohorts of many various most cancers varieties. The uncooked information are publicly accessible at varied Cancer Research Data Commons. However, widespread reuse of these information units can also be facilitated by quick access to the processed quantitative information tables.

We have created an information utility programming interface (API) to distribute these processed tables, carried out as a Python bundle referred to as cptac. We implement it such that customers preferring to work in R can simply use our bundle for information entry and then switch the information into R for evaluation. Our bundle distributes the finalized processed CPTAC information units in a constant, up-to-date format. This consistency makes it straightforward to combine the information with frequent graphing, statistical, and machine-learning packages for superior evaluation.

Additionally, constant formatting throughout all most cancers varieties promotes the investigation of pan-cancer traits. The information API construction of immediately streaming information inside a programming atmosphere enhances the reproducibility. Finally, with the accompanying tutorials, this bundle supplies a novel useful resource for most cancers analysis training. In this overview, we summarize the newest proteomic applied sciences and focus on technical challenges for his or her use in inhabitants research.

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

Proteomics-based interrogation of the kinome and its implications for precision oncology

The identification of particular protein kinases as oncogenic drivers in a range of most cancers varieties, coupled with the medical success of specific kinase-directed focused therapies, has cemented the human kinome as a sexy supply of ‘actionable’ targets for most cancers remedy. However, ‘mining’ of the human kinome for precision oncology functions has but to yield its full potential. This displays a range of points, together with oncogenic kinase dysregulation at ranges not detectable by genomic sequencing and the uncharacterized nature of a substantial fraction of the kinome.

In addition, selective therapeutic focusing on of particular kinases requires environment friendly mapping of whole kinome area impacted by candidate small molecule medicine. Fortunately, latest developments in proteomics strategies, significantly in mass spectrometry-based phosphoproteomics and kinomics, present the mandatory expertise platforms to deal with these impediments. Moreover, initiatives such because the Clinical Proteomic Tumour Analysis Consortium have enabled the technology, deposition and integration of genomic, transcriptomic and (phospho)proteomic information for a lot of most cancers varieties, offering unprecedented insights into oncogenic kinases and most cancers cell signalling usually.

HemoVoid™ LC-MS On-Bead For Erythrocytes Proteomics
HVB-MS05 5 preps
EUR 379
Description: Hemoglobin Removal Kit
HemoVoid™ LC-MS On-Bead For Erythrocytes Proteomics
HVB-MS10 10 preps
EUR 521
Description: Hemoglobin Removal Kit
AGAROSE MS, PCR SCREENING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE
AGR-MS-1001 1/pk
EUR 2038
Description: Bioscience Mol Bio; Agarose
LC-LC(+)-Biotin
abx184150-5g 5 g
EUR 996
  • Shipped within 1-2 weeks.
Human Osteonectin (ON) ELISA Kit
DLR-ON-Hu-48T 48T
EUR 479
  • Should the Human Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Osteonectin (ON) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human Osteonectin (ON) ELISA Kit
DLR-ON-Hu-96T 96T
EUR 621
  • Should the Human Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Osteonectin (ON) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse Osteonectin (ON) ELISA Kit
DLR-ON-Mu-48T 48T
EUR 489
  • Should the Mouse Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Mouse Osteonectin (ON) ELISA Kit
DLR-ON-Mu-96T 96T
EUR 635
  • Should the Mouse Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Osteonectin (ON) ELISA Kit
DLR-ON-Ra-48T 48T
EUR 508
  • Should the Rat Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Osteonectin (ON) ELISA Kit
DLR-ON-Ra-96T 96T
EUR 661
  • Should the Rat Osteonectin (ON) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Osteonectin (ON) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human Osteonectin (ON) ELISA Kit
RDR-ON-Hu-48Tests 48 Tests
EUR 500
Human Osteonectin (ON) ELISA Kit
RDR-ON-Hu-96Tests 96 Tests
EUR 692
Mouse Osteonectin (ON) ELISA Kit
RDR-ON-Mu-48Tests 48 Tests
EUR 511
Mouse Osteonectin (ON) ELISA Kit
RDR-ON-Mu-96Tests 96 Tests
EUR 709
Rat Osteonectin (ON) ELISA Kit
RDR-ON-Ra-48Tests 48 Tests
EUR 534
Rat Osteonectin (ON) ELISA Kit
RDR-ON-Ra-96Tests 96 Tests
EUR 742
Human Osteonectin (ON) ELISA Kit
RD-ON-Hu-48Tests 48 Tests
EUR 478
Human Osteonectin (ON) ELISA Kit
RD-ON-Hu-96Tests 96 Tests
EUR 662
Mouse Osteonectin (ON) ELISA Kit
RD-ON-Mu-48Tests 48 Tests
EUR 489
Mouse Osteonectin (ON) ELISA Kit
RD-ON-Mu-96Tests 96 Tests
EUR 677
Rat Osteonectin (ON) ELISA Kit
RD-ON-Ra-48Tests 48 Tests
EUR 511
Rat Osteonectin (ON) ELISA Kit
RD-ON-Ra-96Tests 96 Tests
EUR 709
AlbuVoid™ Kit
AVK-05 5 preps
EUR 405
Description: Albumin Removal Kit
AlbuVoid™ Kit
AVK-10 10 preps
EUR 552
Description: Albumin Removal Kit
AlbuVoid™ Kit
AVK-50 50 preps
EUR 1547
Description: Albumin Removal Kit
Trypsin, Recombinant, Proteomics grade
P1228-1000
EUR 196
Trypsin, Recombinant, Proteomics grade
P1228-10000
EUR 1224
Trypsin, Recombinant, Proteomics grade
P1228-5000
EUR 615
Biotin-LC-LC-NHS
2346-1000
EUR 1675
Biotin-LC-LC-NHS
2346-250
EUR 588
Biotin-LC-LC-NHS
2346-50
EUR 196
Biotin-LC-LC-NHS
2346-5000 Ask for price
AlbuVoid Binding Buffer AVBB
AVBB-1000 1000 mL
EUR 456
Description: Albuvoid™ Buffer
AlbuVoid Binding Buffer AVBB
AVBB-500 500 mL
EUR 245
Description: Albuvoid™ Buffer
AlbuVoid Buffer Kit - 1000
AVBK-1000 1000 mL
EUR 1166
Description: Albuvoid™ Buffer
AlbuVoid Buffer Kit - 500
AVBK-500 500 mL
EUR 615
Description: Albuvoid™ Buffer
AlbuVoid Elution Buffer AVEB
AVEB-1000 1000 mL
EUR 456
Description: Albuvoid™ Buffer
AlbuVoid Elution Buffer AVEB
AVEB-500 500 mL
EUR 245
Description: Albuvoid™ Buffer
AlbuVoid Wash Buffer AVWB
AVWB-1000 1000 mL
EUR 456
Description: Albuvoid™ Buffer
AlbuVoid Wash Buffer AVWB
AVWB-500 500 mL
EUR 245
Description: Albuvoid™ Buffer
AlbuVoid™ PLUS Kit
NP-AVK-05 5 preps
EUR 405
Description: Albumin Removal Kit
AlbuVoid™ PLUS Kit
NP-AVK10 10 preps
EUR 587
Description: Albumin Removal Kit
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (3 biotin/BSA)
7097-25
EUR 222
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (3 biotin/BSA)
7097-5
EUR 115
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)
7098-25
EUR 233
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)
7098-5
EUR 120
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (12 biotin/BSA)
7099-25
EUR 244
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (12 biotin/BSA)
7099-5
EUR 131
101Bio Protein Solubilization Reagent for MS
P5W11 NULL
EUR 0
Micro Bead Sterlizer
B1201-E 1 PC
EUR 542.7
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.
Micro Bead Sterlizer
B1202-E 1 PC
EUR 84.14
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.
MS-1020
1911-1
EUR 164
Ms-275
20-abx182582
  • EUR 509.00
  • EUR 300.00
  • 100 mg
  • 10 mg
  • Shipped within 1-2 weeks.
MS 275
abx076834-1mg 1 mg
EUR 314
  • Shipped within 5-12 working days.
MS-1020
GL5031-1MG 1 mg
EUR 160
Refill Glass Beads
B1201-BEAD 1 PC
EUR 117.78
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.
LC-Protein Kinase G Substrate; LC-Gsubtide (Biotin)
20-abx265657
  • EUR 467.00
  • EUR 773.00
  • EUR 356.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.
ELISA kit for Human MS (Melatonin Sulfate)
E-EL-H1726 1 plate of 96 wells
EUR 534
  • Gentaur's MS ELISA kit utilizes the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with Human MS. During the reaction, Human MS in the sample or standard competes with a fixed amount of Human MS on the sol
  • Show more
Description: A competitive ELISA kit for quantitative measurement of Human MS (Melatonin Sulfate) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Human Melatonin sulfate (MS)
KTE61523-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Melatonin sulfate (MS)
KTE61523-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Melatonin sulfate (MS)
KTE61523-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Melatonin sulfate (MS) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Kininogen LC antibody
23031-100ul 100ul
EUR 390
Sulfo-LC-SPDP
2325-250
EUR 1567
Sulfo-LC-SPDP
2325-50
EUR 436
Biotin-LC-NHS
2345-1000
EUR 1001
Biotin-LC-NHS
2345-250
EUR 419
Biotin-LC-NHS
2345-50
EUR 142
Biotin-LC-Kemptide
5-00800 4 x 1mg Ask for price
CD49f LC antibody
70R-49925 100 ul
EUR 244
Description: Purified Polyclonal CD49f LC antibody
CD49e LC antibody
70R-49932 100 ul
EUR 244
Description: Purified Polyclonal CD49e LC antibody
CD49e LC Antibody
20-abx009097
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
CD49f LC Antibody
20-abx009102
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
sulfo-LC-(+)-Biotin
20-abx185570
  • EUR 370.00
  • EUR 1261.00
  • EUR 578.00
  • 100 mg
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.
LC-(+)-Biotin hydrazide
abx185659-1g 1 g
EUR 648
  • Shipped within 1-2 weeks.
LC-NHS-(+)-Biotin
20-abx185861
  • EUR 634.00
  • EUR 398.00
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.
CD224 LC Antibody
20-abx121054
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Enteropeptidase LC Antibody
20-abx121089
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
MASP1 LC Antibody
20-abx121154
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Myeloperoxidase LC Antibody
20-abx121172
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
sulfo-LC-SPDP
ADC-L-133 unit Ask for price
NHS-LC-Biotin
A8004-100 100 mg
EUR 119
Description: NHS-LC-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as NHS-X-biotin is a derivative of D-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of D-biotin with an NHS ester group at its end.
NHS-LC-Biotin
A8004-1000 1 g
EUR 548
Description: NHS-LC-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as NHS-X-biotin is a derivative of D-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of D-biotin with an NHS ester group at its end.
Iodoacetyl-LC-Biotin
A8009-100 100 mg
EUR 264
Description: Iodoacetyl-LC-Biotin (N-iodoacetyl-N-biotinylhexylenediamine), a sulfhydryl-reactive biotinylation agent, is a water-insoluble reagent that requires the dissolution of suitable solvents, including dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).
Biotin LC hydrazide
HY-101885 5mg
EUR 119
pPINK- LC Plasmid
PVT4035 2 ug
EUR 325
BrightGreen miRNA qPCR MasterMix-No Dye
MasterMix-mS 4 x 1.25 ml for 500 reactions
EUR 151
Bangs Lab Bead Solution
SOLN1-1000 1000 ML
EUR 155.06
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres
Bangs Lab Bead Solution
SOLN1-2000 2000 ML
EUR 212.7
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres
Bangs Lab Bead Solution
SOLN1-500 500 ML
EUR 98.51
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres
uv lamp 2x15w, 254/365nm
VL215-LC ea
EUR 817
uv lamp 2x6w, 254/365nm
VL6-LC ea
EUR 538
darkroom 254/365nm
VLCN15-LC ea
EUR 1535
CLIA kit for Human ON (Osteonectin)
E-CL-H0889 1 plate of 96 wells
EUR 584
  • Gentaur's ON CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human ON . Standards or samples are added to the micro CLIA plate wells and combined with the spec
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Human ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
CLIA kit for Mouse ON (Osteonectin)
E-CL-M0530 1 plate of 96 wells
EUR 584
  • Gentaur's ON CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse ON . Standards or samples are added to the micro CLIA plate wells and combined with the spec
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Mouse ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
CLIA kit for Rat ON (Osteonectin)
E-CL-R0498 1 plate of 96 wells
EUR 584
  • Gentaur's ON CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Rat ON . Standards or samples are added to the micro CLIA plate wells and combined with the specif
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Rat ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Human ON (Osteonectin)
E-EL-H1351 1 plate of 96 wells
EUR 534
  • Gentaur's ON ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human ON. Standards or samples are added to the micro ELISA plate wells and combined with the sp
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Human ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Mouse ON (Osteonectin)
E-EL-M0867 1 plate of 96 wells
EUR 534
  • Gentaur's ON ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse ON. Standards or samples are added to the micro ELISA plate wells and combined with the sp
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Mouse ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Rat ON (Osteonectin)
E-EL-R0701 1 plate of 96 wells
EUR 534
  • Gentaur's ON ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat ON. Standards or samples are added to the micro ELISA plate wells and combined with the spec
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Rat ON (Osteonectin) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Human ON (Osteonectin)
ELK1682 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Osteonectin (ON). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Osteonectin (ON).
  • Show more
Description: A sandwich ELISA kit for detection of Osteonectin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for Rat ON (Osteonectin)
ELK1683 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Osteonectin (ON). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Osteonectin (ON).
  • Show more
Description: A sandwich ELISA kit for detection of Osteonectin from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for Mouse ON (Osteonectin)
ELK1684 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Osteonectin (ON). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Osteonectin (ON).
  • Show more
Description: A sandwich ELISA kit for detection of Osteonectin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for Human Osteonectin (ON)
KTE60336-48T 48T
EUR 354
  • Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone min
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Osteonectin (ON)
KTE60336-5platesof96wells 5 plates of 96 wells
EUR 2252
  • Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone min
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Osteonectin (ON)
KTE60336-96T 96T
EUR 572
  • Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone min
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Osteonectin (ON) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
MS 245 oxalate
B5540-10 10 mg
EUR 292
MS 245 oxalate
B5540-5 5 mg
EUR 210
Methyl-PEG3-MS
abx186609-250mg 250 mg
EUR 439
  • Shipped within 1-2 weeks.
MS-275 (Entinostat)
E1KS1053 25 mg
EUR 247
Biotin-LC-Protein Kinase G Substrate; Biotin-LC-G-Subtide
5-00802 4 x 5mg Ask for price
Sulfo-NHS-LC-Biotin
2326-100
EUR 311
Sulfo-NHS-LC-Biotin
2326-50
EUR 202
Sulfo-NHS-LC-Biotin
2326-set
EUR 213
Polyclonal CD49e LC Antibody
APR05533G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD49e LC . This antibody is tested and proven to work in the following applications:
Complement C1R LC antibody
70R-49435 100 ul
EUR 244
Description: Purified Polyclonal Complement C1R LC antibody
Cathepsin D LC antibody
70R-49618 100 ul
EUR 244
Description: Purified Polyclonal Cathepsin D LC antibody
Cathepsin D LC Antibody
20-abx009376
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Complement C1R LC Antibody
20-abx009532
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Cathepsin C LC Antibody
20-abx121043
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
CD41 LC 1 Antibody
20-abx121061
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Factor IX LC Antibody
20-abx121094
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Factor XI LC Antibody
20-abx121097
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
CD224 LC Blocking Peptide
20-abx161054
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
Enteropeptidase LC Blocking Peptide
20-abx161089
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
MASP1 LC Blocking Peptide
20-abx161154
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
Myeloperoxidase LC Blocking Peptide
20-abx161172
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
CD49f LC Blocking Peptide
20-abx062800
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
CD49e LC Blocking Peptide
20-abx062807
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
LC-Kemptide (Biotin) Peptide
20-abx265999
  • EUR 384.00
  • EUR 592.00
  • EUR 300.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.
Sulfo-NHS-LC-Biotin
A8003-100 100 mg
EUR 142
Description: Sulfo-NHS-LC-biotin (Sulfosuccinimidyl 6-(biotinamido) Hexanoate) is an amine-reactive biotinylation agent.
Sulfo-NHS-LC-Biotin
A8003-1000 1 g
EUR 572
Description: Sulfo-NHS-LC-biotin (Sulfosuccinimidyl 6-(biotinamido) Hexanoate) is an amine-reactive biotinylation agent.
ExoFACS? Kit for Serum Exosomes
K1233-20
EUR 794
AffiPure Ni-NTA Agarose Bead,For His-Tagged Protein Purification
N3505-010 10ml
EUR 317
AffiPure Ni-NTA Agarose Bead,For His-Tagged Protein Purification
N3505-050 50ml
EUR 833

These multi-omic information are figuring out novel therapeutic targets, highlighting alternatives for drug re-purposing, and serving to assign optimum therapies to particular tumour subtypes, heralding a brand new period of ‘enhanced’ precision oncology. This article is protected by copyright. All rights reserved. These species variations in plasma protein temporal responses may contribute to the pronounced most cancers resistance noticed in bare mole-rats. Proteomic applied sciences now allow the fast quantification of 1000’s of proteins throughout genetically numerous samples. Integration of these information with systems-genetics analyses is a robust strategy to establish new regulators of economically necessary or disease-relevant phenotypes in varied populations.

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