Protein – Proteomics Consortium

Use of Hybrid Data-Dependent and -Independent Acquisition Spectral Libraries Empowers Dual-Proteome Profiling

By Hugh Dixon
April 16, 2021
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In the context of bacterial infections, it’s crucial that physiological responses could be studied in an built-in method, which means a simultaneous evaluation of each the host and the pathogen … Continue Reading →

$The identification of specific protein kinases as oncogenic drivers in a variety of cancer sorts, coupled with the clinical success of particular kinase-directed targeted therapies, has cemented the human kinome as an attractive source of 'actionable' targets for cancer remedy. However, 'mining' of the human kinome for precision oncology applications has yet to yield its full potential. This reflects a variety of points, including oncogenic kinase dysregulation at levels not detectable by genomic sequencing and the uncharacterized nature of a considerable fraction of the kinome. In addition, selective therapeutic targeting of specific kinases requires efficient mapping of total kinome space impacted by candidate small molecule medication. Fortunately, recent developments in proteomics strategies, particularly in mass spectrometry-based phosphoproteomics and kinomics, provide the necessary technology platforms to address these impediments. Moreover, initiatives such as the Clinical Proteomic Tumour Analysis Consortium have enabled the era, deposition and integration of genomic, transcriptomic and (phospho)proteomic data for many cancer sorts, providing unprecedented insights into oncogenic kinases and cancer cell signalling typically. These multi-omic data are identifying novel therapeutic targets, highlighting opportunities for drug re-purposing, and helping assign optimal therapies to specific tumour subtypes, heralding a new era of 'enhanced' precision oncology. This article is protected by copyright. All rights reserved.$

Human pores and skin is composed of the cell-rich dermis, the extracellular matrix (ECM) wealthy dermis, and the hypodermis.

By Hugh Dixon
April 11, 2021
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Within the dermis, a dense community of ECM proteins offers structural assist to the pores and skin and regulates a large variety of signaling pathways which govern cell proliferation and … Continue Reading →

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

By Hugh Dixon
March 11, 2021
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Proteomic signatures associated with medical measures of extra aggressive cancers may yield molecular clues as to illness drivers. Here, using the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets, we outlined differentially expressed proteins and mRNAs … Continue Reading →

An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community

By Hugh Dixon
March 11, 2021
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Precise multiplexed quantification of proteins in organic samples will be achieved by focused proteomics utilizing a number of or parallel response monitoring (MRM/PRM). Combined with inside requirements, the methodology achieves excellent repeatability … Continue Reading →

Mouse Cd3e & Cd3g Heterodimer Protein Bio-Connect

By Hugh Dixon
January 12, 2020
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Catalog Number: 444-CT073-M0302H Category: Protein Supplier: Bio-Connect Species: Mouse To order Mouse Cd3e & Cd3g Heterodimer Protein from Bio-Connect Contact info@proteomeconsortium.org Rpmi 1640 Without L Glutamine Glucose Monkey Esophagus Total … Continue Reading →

Mouse Anri Zika Virus Envelop Protein Alpha Diagnostics

By Hugh Dixon
January 12, 2020
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Catalog Number: 15-RV-403120-1 Category: Protein Supplier: Alpha Diagnostics Species: Mouse To order Mouse Anri Zika Virus Envelop Protein from Alpha Diagnostics Contact info@proteomeconsortium.org Cytidine Deaminase Activity Assay Kit Hemoglobin Colorimetric … Continue Reading →

Oxiselect Protein Carbonyl Immunoblot Cell BioLabs

By Hugh Dixon
January 12, 2020
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Catalog Number: 197-STA-308-T Category: Protein Supplier: Cell BioLabs To order Oxiselect Protein Carbonyl Immunoblot from Cell BioLabs Contact info@proteomeconsortium.org Deproteinizing Sample Preparation Kit Super PIgGybac Transposase Expression Neptune Barrierstips 1250 … Continue Reading →

Mouse CD3d CD3 Delta Protein Fc Tag Bio-Connect

By Hugh Dixon
January 12, 2020
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Catalog Number: 444-50390-M02H Category: Protein Supplier: Bio-Connect Species: Mouse To order Mouse CD3d CD3 Delta Protein Fc Tag from Bio-Connect Contact info@proteomeconsortium.org Dmem Low Glucose Without Amino Acids Human Putative … Continue Reading →

Mouse Cd3d & Cd3e Hetrodimer Protein Bio-Connect

By Hugh Dixon
January 12, 2020
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Catalog Number: 444-CT025-M2303H Category: Protein Supplier: Bio-Connect Species: Mouse To order Mouse Cd3d & Cd3e Hetrodimer Protein from Bio-Connect Contact info@proteomeconsortium.org Cell Culture Media Bovine Ivf Media Anti G3pdh Human … Continue Reading →

Active Tau P301s Protein Pre Formed Stressmarq

By Hugh Dixon
January 12, 2020
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Catalog Number: 400-SPR-329E Category: Protein Supplier: Stressmarq Biosciences Inc To order Active Tau P301s Protein Pre Formed from Stressmarq Biosciences Inc Contact info@proteomeconsortium.org Zo 1 Pab Alexa Fluor 488 Conjugated … Continue Reading →