Proteomics Consortium – info@proteomeconsortium.org

Use of Hybrid Data-Dependent and -Independent Acquisition Spectral Libraries Empowers Dual-Proteome Profiling

By Hugh Dixon
April 16, 2021
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In the context of bacterial infections, it’s crucial that physiological responses could be studied in an built-in method, which means a simultaneous evaluation of each the host and the pathogen … Continue Reading →

$The identification of specific protein kinases as oncogenic drivers in a variety of cancer sorts, coupled with the clinical success of particular kinase-directed targeted therapies, has cemented the human kinome as an attractive source of 'actionable' targets for cancer remedy. However, 'mining' of the human kinome for precision oncology applications has yet to yield its full potential. This reflects a variety of points, including oncogenic kinase dysregulation at levels not detectable by genomic sequencing and the uncharacterized nature of a considerable fraction of the kinome. In addition, selective therapeutic targeting of specific kinases requires efficient mapping of total kinome space impacted by candidate small molecule medication. Fortunately, recent developments in proteomics strategies, particularly in mass spectrometry-based phosphoproteomics and kinomics, provide the necessary technology platforms to address these impediments. Moreover, initiatives such as the Clinical Proteomic Tumour Analysis Consortium have enabled the era, deposition and integration of genomic, transcriptomic and (phospho)proteomic data for many cancer sorts, providing unprecedented insights into oncogenic kinases and cancer cell signalling typically. These multi-omic data are identifying novel therapeutic targets, highlighting opportunities for drug re-purposing, and helping assign optimal therapies to specific tumour subtypes, heralding a new era of 'enhanced' precision oncology. This article is protected by copyright. All rights reserved.$

Human pores and skin is composed of the cell-rich dermis, the extracellular matrix (ECM) wealthy dermis, and the hypodermis.

By Hugh Dixon
April 11, 2021
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Within the dermis, a dense community of ECM proteins offers structural assist to the pores and skin and regulates a large variety of signaling pathways which govern cell proliferation and … Continue Reading →

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

By Hugh Dixon
March 11, 2021
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Proteomic signatures associated with medical measures of extra aggressive cancers may yield molecular clues as to illness drivers. Here, using the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets, we outlined differentially expressed proteins and mRNAs … Continue Reading →

An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community

By Hugh Dixon
March 11, 2021
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Precise multiplexed quantification of proteins in organic samples will be achieved by focused proteomics utilizing a number of or parallel response monitoring (MRM/PRM). Combined with inside requirements, the methodology achieves excellent repeatability … Continue Reading →

Magnetic Beads Proteomics

By Hugh Dixon
September 3, 2020
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cat name size price MD01009 Magnetic Beads Proteomics C18 2 milliliters 290.4 MD03009 Magnetic Beads Proteomics C18 10 milliliters 1024.8 MD04009 Magnetic Beads Proteomics C18 100 milliliters 5497.5 MD01014 Magnetic … Continue Reading →

MagSi proteomics

By Hugh Dixon
September 3, 2020
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Cat Name Size Price MD01009 MagSi-proteomics C18 2 mL 425 MD03009 MagSi-proteomics C18 10 mL 1160 MD04009 MagSi-proteomics C18 100 mL 5633 MD01014 MagSi-proteomics C4 2 mL 425 MD02014 MagSi-proteomics … Continue Reading →

Protease Guide For Tag Removal

By Hugh Dixon
July 7, 2020
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The use of affinity tags has become a very useful tool when it comes to expressing proteins recombinantly , greatly facilitating their purification and detection, increasing performance and solubility on certain occasions, and even … Continue Reading →

Proteomics Ressources Plugins

By Hugh Dixon
June 11, 2020
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Autonom Biopendium Please login Then, select a licensed product from the list of available downloads. *If you do not have an MDL Web account, you must register and obtain an … Continue Reading →

Experimental data from flesh quality assessment and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets.

By Hugh Dixon
May 19, 2020
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Fresh fish are extremely perishable meals merchandise and their brief shelf-life limits their industrial exploitation and results in waste, which has a detrimental influence on aquaculture sustainability. New non-thermal meals … Continue Reading →

HSD17B4, ACAA1, and PXMP4 in Peroxisome Pathway Are Down-Regulated and Have Clinical Significance in Non-small Cell Lung Cancer.

By Hugh Dixon
May 19, 2020
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To discover the potential capabilities and scientific significances of peroxisomes throughout lung most cancers growth and development, we investigated the expressional profiles of peroxisome pathway genes and their correlations with … Continue Reading →