Tissue – Proteomics Consortium

Use of Hybrid Data-Dependent and -Independent Acquisition Spectral Libraries Empowers Dual-Proteome Profiling

By Hugh Dixon
April 16, 2021
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In the context of bacterial infections, it’s crucial that physiological responses could be studied in an built-in method, which means a simultaneous evaluation of each the host and the pathogen … Continue Reading →

$The identification of specific protein kinases as oncogenic drivers in a variety of cancer sorts, coupled with the clinical success of particular kinase-directed targeted therapies, has cemented the human kinome as an attractive source of 'actionable' targets for cancer remedy. However, 'mining' of the human kinome for precision oncology applications has yet to yield its full potential. This reflects a variety of points, including oncogenic kinase dysregulation at levels not detectable by genomic sequencing and the uncharacterized nature of a considerable fraction of the kinome. In addition, selective therapeutic targeting of specific kinases requires efficient mapping of total kinome space impacted by candidate small molecule medication. Fortunately, recent developments in proteomics strategies, particularly in mass spectrometry-based phosphoproteomics and kinomics, provide the necessary technology platforms to address these impediments. Moreover, initiatives such as the Clinical Proteomic Tumour Analysis Consortium have enabled the era, deposition and integration of genomic, transcriptomic and (phospho)proteomic data for many cancer sorts, providing unprecedented insights into oncogenic kinases and cancer cell signalling typically. These multi-omic data are identifying novel therapeutic targets, highlighting opportunities for drug re-purposing, and helping assign optimal therapies to specific tumour subtypes, heralding a new era of 'enhanced' precision oncology. This article is protected by copyright. All rights reserved.$

Human pores and skin is composed of the cell-rich dermis, the extracellular matrix (ECM) wealthy dermis, and the hypodermis.

By Hugh Dixon
April 11, 2021
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Within the dermis, a dense community of ECM proteins offers structural assist to the pores and skin and regulates a large variety of signaling pathways which govern cell proliferation and … Continue Reading →

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

By Hugh Dixon
March 11, 2021
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Proteomic signatures associated with medical measures of extra aggressive cancers may yield molecular clues as to illness drivers. Here, using the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets, we outlined differentially expressed proteins and mRNAs … Continue Reading →

An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community

By Hugh Dixon
March 11, 2021
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Precise multiplexed quantification of proteins in organic samples will be achieved by focused proteomics utilizing a number of or parallel response monitoring (MRM/PRM). Combined with inside requirements, the methodology achieves excellent repeatability … Continue Reading →

Bone Tumor And Adjacent Normal Tissue US Biomax

By Hugh Dixon
January 12, 2020
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Catalog Number: 131-BM483c Category: Tissue Supplier: US Biomax To order Bone Tumor And Adjacent Normal Tissue from US Biomax Contact info@proteomeconsortium.org Second Strand cDNA Synthesis Kit Dntp Phosphoglycerate Dehydrogenase Phgdh … Continue Reading →

Central Nerve Disease Spectrum Tissue US Biomax

By Hugh Dixon
January 12, 2020
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Catalog Number: 131-CNS2081 Category: Tissue Supplier: US Biomax To order Central Nerve Disease Spectrum Tissue from US Biomax Contact info@proteomeconsortium.org Grpr Egfp Lentiviral Vector Human CMV Monoamine Oxidase Activity Total … Continue Reading →

Mouse Frozen Sections Adult Tissues Zyagen

By Hugh Dixon
January 12, 2020
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Catalog Number: 62-MF-901 Category: Tissue Supplier: Zyagen Species: Mouse To order Mouse Frozen Sections Adult Tissues from Zyagen Contact info@proteomeconsortium.org Comptrol Gt Anti Ms Ig H&L Particles Human Anti Poliomyelitis … Continue Reading →

Tissue Total RNA Human Adult Normal Mybiosource

By Hugh Dixon
January 12, 2020
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Catalog Number: 544-MBS638541-0.01 Category: Tissue Supplier: Mybiosource Species: Human To order Tissue Total RNA Human Adult Normal from Mybiosource Contact info@proteomeconsortium.org Monkey Stomach Total RNA Cynomolgus Accudenz A.G. Cell Separation … Continue Reading →

Total RNA Human Adult Normal Tissue Biochain

By Hugh Dixon
January 12, 2020
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Catalog Number: 36-R1234218-50 Category: Tissue Supplier: Biochain Species: Human To order Total RNA Human Adult Normal Tissue from Biochain Contact info@proteomeconsortium.org Qne Hyaluronic Acid Ha Quantitative Tissue Total RNA Human … Continue Reading →

Malignant Melanoma With Skin Tissue US Biomax

By Hugh Dixon
January 12, 2020
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Catalog Number: 131-ME2082d Category: Tissue Supplier: US Biomax To order Malignant Melanoma With Skin Tissue from US Biomax Contact info@proteomeconsortium.org Gfp Blank miRNA MicroRNA Lentivirus Insulin Calibrator 5 Concentrations Epiquik … Continue Reading →

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